Crestor, or rosuvastatin, is an oral lipid-lowering agent widely used for managing dyslipidemia and hypercholesterolemia due to its antihyperlipidemic effect and potential to reduce cardiovascular morbidity and mortality [
]. The principal mode of lipid-lowering efficacy is through inhibiting lipase, an enzyme that is essential for cholesterol synthesis. Rosuvastatin, however, possesses a lower lipid content than Crestor, and the mechanism of action is different, though the optimal lipid-lowering efficiency is still unclear [
,
In this context, the lipid-lowering efficacy of rosuvastatin is mainly determined by its capacity to inhibit lipase, an enzyme required for hydrolyzing triglyceride, and its ability to modulate the expression and activity of HMG-CoA reductase. In this context, the pharmacological action of rosuvastatin, as well as its lipid-lowering capacity, can be further investigated [
In this study, rosuvastatin was evaluated in mice with hyperlipidemia, and its effect was assessed in terms of lipid profile and the expression of HMG-CoA- reductase. Additionally, lipid-lowering capacity of rosuvastatin in mice with hypercholesterolemia was investigated, as it may influence the therapeutic response and overall clinical outcome.
This study was approved by the Research Ethics Committee of the Sichuan University (Approval No. 2018-0004), and was registered in the Chinese Medical Journal (CJCMJ0002021).
All the animals were obtained from animal care and management committee at the University of Shanghai. Male C57BL/6 mice (5-6 week-old) were purchased from Vital River Laboratory (Wuhan, China). The animals were fed standard chow diet (LD12, LD10, and LD20) at normal or high-fat diet. The animals were treated daily with rosuvastatin (1000mg/day) for 3 weeks. In addition, the animals were kept under laboratory conditions with a 12 h light-dark cycle, and the diet contained natural organic and natural components, including cornified flour, tap water, cotton seed, walnuts, flaxseeds, and flaxseeds. All the experimental procedures were carried out in accordance with the approved guidelines.
To detect lipid levels, the mice were anesthetized with intraperitoneal ketamine (100mg/kg), and they were then sacrificed by cervical dislocation. The liver samples were collected, and the liver was collected in the same manner as those used for analysis. The liver was lysed in lysate buffer (100mL) containing the lipid peroxidation inhibitor p-nitrophenyl-glycerol, and the cell lysate was subjected to further analysis. Then, the enzyme-linked immunosorbent assay (ELISA) (Abcam, Inc., USA) was used to detect lipid levels in liver. The mice were then anesthetized with 4% isoflurane, and the abdomen was opened. The abdomen was then closed and the heart was isolated and collected, and then the liver was removed, and the liver was weighed. Finally, the liver was separated from the abdomen, washed by centrifugation, and suspended in distilled water and then placed in a water bath for 30 min at room temperature. The supernatant was collected and used for lipid profile analysis. All the other chemicals were purchased from China Chemical Society (Shanghai, China).
To our knowledge, this is the first report that rosuvastatin can effectively reduce the lipid-lowering capacity of a statin in mice with hyperlipidemia. We found that rosuvastatin had a lower lipid-lowering capacity than Crestor. Furthermore, lipid-lowering capacity of rosuvastatin was decreased in mice with hypercholesterolemia, which was consistent with our previous study [
In this study, the lipid-lowering capacity of rosuvastatin was decreased in mice with hypercholesterolemia. Furthermore, rosuvastatin reduced the expression of HMG-CoA- reductase, as evidenced by the western blot and ELISA assay. Additionally, the expression of HMG-CoA- reductase was increased in mice with hypercholesterolemia, which was consistent with our previous study [
CRESTOR 10MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.
By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 10MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.
Before taking CRESTOR 10MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
CRESTOR 10MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 10MG TABLET as a precaution.
The most common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 10MG TABLET.
How should I take CRESTOR 10MG TABLET? CRESTOR 10MG TABLET should be taken according to your doctor instructions. Some common side effects of taking CRESTOR 10MG TABLET include muscle pain, tenderness or weakness, including infants and elderly patients. It is advised to avoid taking CRESTOR 10MG TABLET in the past as they may be causingGETHEARTBEARENoconstensionmycoplasmosis Bronchitis iliacis Through diet and exercise a regular exercise program includes eating a well-balanced diet and engaging in regular physical activity “Ad CV Care" “.The amount of time CRESTOR 10MG TABLET takes to effects varies from person to person, but it can take up to 4 weeks before you experience side effects. It's important to consult your doctor before starting treatment with CRESTOR 10MG TABLET for any underlying medical conditions as long as you are taking this medication.
Inform your doctor if you have a history of heart attack, stroke, liver disease, kidney disease, retinitis pigmentosa faecia, back pain or muscle pain.
The effects of taking CRESTOR 10MG TABLET are not recommended in patients with a history of blood-related disorders, including hypertension, diabetes, high cholesterol, high blood pressure, abnormal heart rhythm, fungal or yeast infections of the mouth, throat, vagina, and itching.
Do not take CRESTOR 10MG TABLET if you are taking nitrates,use drug interactions including chest or leg pain, ischemic stroke, stroke, back pain or muscle pain, as long as your doctor has prescribed this medication.
Taking alcohol while taking CRESTOR 10MG TABLET can increase your blood pressure, patient anxiety, kidney disease, and affect kidney function. You must consult your doctor before starting treatment with this medicine for any alcohol-related side effects.
Some possible reasons for low blood pressure include high blood pressure, heat stroke or cold, pregnancy, lactosey reactions.
Common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache.Sold and Supplied by Healthylife Pharmacy
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Healthylife Product InformationProduct informationHealthylife street name HealthylifeHealthylife is a prescription only medicine (S4) and is sold by Healthylife Pharmacy, an independently owned and operated pharmacy business. This drug requires a prescription. Please ensure you have a valid Australian script. Healthylife is a prescription drug, which requires a prescription. Use our contact details to chat about your purchase and to confirm that the pharmacy is genuine and providing safe, effective service. If you require information toniaegrams
Active as: Rosuvastatin calciumManufacturerBrand:Care Pharmaceuticals dosage:40 tablets
Prescription only20 tablets
Treatment of benign prostatic hyperplasia (BPH)
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Country of OriginHealthylife is available in the UK only for prescriptions. Healthylife is a prescription prescription drug that Healthylife supply is made in Australia. Healthylife requires a prescription in Australia. If you are allergic to Rosuvastatin calcium, then you may be allergic to other ingredients in this medicine (see section 2 "How to Dose a Prescription Only Prescription Only Drug".
Generic forRosuvastatin calcium:Rosuvastatin calcium is a brand name for Crestor (rosuvastatin). Rosuvastatin calcium is a prescription drug that Healthylife ships worldwide. Contact Healthylife at once if you are not sure if you are taking any prescription drug.
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Healthylife does notAlways use alcohol as a livelihood in some cases. Speak to your pharmacist or doctor before trying to drive if you are taking any other medications.
Healthylife is a prescription medication that is usually taken once or twice daily with or without food. If you take this medication regularly it can cause a number of unwanted side effects, including:
If you take this medication regularly, you may experience side effects.
Crestor and other anti-cholesterol drugs have been found to cause high cholesterol levels. In one case, a customer complained of a rash while shopping at a Target pharmacy, and the doctor recommended that he stop use the medication. The customer, who had been taking a cholesterol drug, asked the doctor to switch him to the brand-name drug Crestor, a statin drug that lowers the bad cholesterol.
“My wife and I are having difficulty staying in touch with our doctor and their help,” said a customer who asked the doctor to switch him to the brand-name drug. “We’ve been on Crestor for a few years. We’ve tried other drugs that are no longer prescribed and are no longer being prescribed.”
The prescription-only cholesterol-lowering drugs have been found to cause high cholesterol levels.
“I’m not sure I’m taking the correct dosage,” said the customer. “I’m taking a statin and this will affect my liver function.”
“We’ve tried other drugs and there is no benefit.”
“I have read that patients are more likely to experience serious side effects when taking an anti-cholesterol medication like Crestor,” said the patient.
“I’ve been on a lot of the anti-cholesterol drugs for the last several years. I’ve been having some side effects, but I’m not sure whether or not it’s safe,” said the customer. “I have been on Crestor for about six months. I can’t seem to stop taking it and I’m not getting any side effects.”
“My wife is suffering from liver and kidney issues, so I have had to switch her to Crestor,” said the customer. “I’ve had no side effects and I’m not worried.”
“My wife has been taking the cholesterol drug Crestor for six months. She has been very ill for a long time,” said the customer. “She has had to take it for six months. I have been taking it for six months.”
“My wife is very sick and I think she’s been taking it for a couple of months. I have taken her for a week and have had no side effects. I can’t tell you how many times have I taken her,” added the customer. “I have had no side effects and I’m not worried.”
A customer with a headache during the week and a rash when taking a cholesterol drug“It’s really annoying, but it’s not a big deal. It just goes away once you start taking it,” said the customer.
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